Endocrine Abstracts

Over 60 generations we have inbred a strain of rats to maximize urine calcium excretion, the most common metabolic abnormality in human stone formers. The rats now excrete 8 - 10 times as much calcium as controls and uniformly form kidney stones. They have been termed genetic hypercalciuric stone forming (GHS) rats. The GHS rats exhibit metabolic abnormalities similar to patients with idiopathic hypercalciuria in that they absorb excessive amounts of intestinal calcium, they f...